abstract：:Suppressor monocytes have been found in a number of human diseases most of which are associated with lymphopenia and deficiences in cell mediated immunity. In our studies both quantitative and qualitative differences in monocytes were detected in certain patients with advanced Hodgkin's disease or tuberculosis. In cer...

journal_title：Advances in experimental medicine and biology

authors： Schechter GP,Wahl LM,Oppenheim JJ

更新日期：1979-01-01 00:00:00

abstract：:1. Rat skeletal muscle can synthesize purine nucleotides de novo. 2. Nucleotide synthesis de novo was inhibited by approximately 90% in the presence of 1 mM azaserine. 3. Purine nucleotides can be synthesized via "salvage" pathways from purine bases and nucleosides. Under the conditions employed incorporation rates we...

journal_title：Advances in experimental medicine and biology

authors： Tully ER,Sheehan TG

更新日期：1979-01-01 00:00:00

abstract：:Allospecific suppressor T cells can be generated by allostimulating thymus, spleen and lymph node cells in culture. Bone marrow cells do not yield suppressor lymphocytes. While the efficiency of thymocytes for suppressor cell generation decreases with the age of thymus donors, the efficiency of spleen increases with a...

journal_title：Advances in experimental medicine and biology

authors： Eisenthal A,Nachtigal D,Feldman M

更新日期：1979-01-01 00:00:00

abstract：:As porcine corpus luteum tissue ages there is an increase in amount of LH/hCG vinding inhibitor. This inhibitor is absent in non-luteal ovarian tissue, heart and lung. ...

journal_title：Advances in experimental medicine and biology

authors： Tucker S,Kumari L,Channing CP

更新日期：1979-01-01 00:00:00

abstract：:Purification of angiotensin I-converting enzyme from human lung and characteristics of the enzyme was studied. Experimental pneumonitis was produced in rabbits and the change of the activity of angiotensin I-converting enzyme was studied in purpose to clarify the role of this enzyme in the metabolism of vasoactive pep...

journal_title：Advances in experimental medicine and biology

authors： Kokubu T,Ueda E,Joh T,Nishimura K

更新日期：1979-01-01 00:00:00

abstract：:Studies on the gonadotrophin-responsive adenylyl cyclase (AC) system of rabbit and porcine ovarian follicles reveal that hCG or LH-induced desensitization of the AC system can be divided into two phases: an initial, LH-specific phase and a second phase which is not specific for LH. The first phase occurs within the fi...

journal_title：Advances in experimental medicine and biology

authors： Hunzicker-Dunn M,Jungmann R,Derda D,Birnbaumer L

更新日期：1979-01-01 00:00:00

abstract：:In summary, we have presented evidence which relates to the action pathway of hormonal control of glycogen metabolism. In the case of insulin, there are changes demonstrable in the cyclic AMP-dependent protein kinase and also in the phosphoprotein phosphatase, under conditions where no direct relationship to either cy...

journal_title：Advances in experimental medicine and biology

authors： Larner J,Roach PJ,Huang LC,Brooker G,Murad F,Hazen R

更新日期：1979-01-01 00:00:00

abstract：:Differences between serum and plasma complement, which now is called as the cold activation of complement, was investigated in relation with the phenomenon reported as the cold promoted activation of factor VII, to which kallikrein and Hageman factor are known to participate. Despite the presence of several similariti...

journal_title：Advances in experimental medicine and biology

authors： Kondo M,Takemura S,Yoshikawa T,Kato H,Yokoe N,Ikezaki M,Hosokawa K,Masuda M

更新日期：1979-01-01 00:00:00

abstract：:The effects of sensory stimulation on the release of amino acids from sensori-motor and visual cortices have been studied using a superfusion technique. Electrical stimulation of the brachial plexus contra-lateral to the superfusion cannula increased significantly the release of glutamate and glutamine from the sensor...

journal_title：Advances in experimental medicine and biology

authors： Abdul-Ghani AS,Bradford HF,Cox DW,Dodd HF

更新日期：1979-01-01 00:00:00

abstract：:Based on studies using 3H-DFP as an active site titrant, it is suggested that surface binding in itself does not result in the formation of new active sites in the Hageman factor molecule. Moreover, it was found that surface-binding of human and bovine Hageman factor renders these molecules 100 to 1000 times more susc...

journal_title：Advances in experimental medicine and biology

authors： Griffin JH,Beretta G

更新日期：1979-01-01 00:00:00

abstract：:Since plasma is a homogenous fluid its biochemical systems need special control mechanisms to prevent their unlimited and continuous activity. In general, enzymic activity is not preformed but generated by trigger processes. Activation is then enhanced by cascade reactions. It can be controlled by enzyme inhibitors, b...

journal_title：Advances in experimental medicine and biology

authors： Vogt W

更新日期：1979-01-01 00:00:00

abstract：:Using fowl anti mouse (Fab)2 antibody, a protein has been collected from culture fluid and cell lysates of thymoma cells and stimulated thymocytes. This protein did show an immunoglobulin arc on immunoelectrophoresis against abovementioned antibody and against rabbit anti mouse Ig serum. No precipitation lines have be...

journal_title：Advances in experimental medicine and biology

authors： Szenberg A

更新日期：1979-01-01 00:00:00

abstract：:There is a positive correlation between lactate output and insulin secretion but there is no correlation between total islet PEP content and insulin secretion and no correlation between cAMP production and insulin release. Neither PEP or cAMP seem to be primary triggers to insulin release but may rather act as positiv...

journal_title：Advances in experimental medicine and biology

authors： Hedeskov CJ,Capito K

更新日期：1979-01-01 00:00:00

abstract：:1) The immunological mechanism of protection against dental caries has been investigated by passive immunization with antisera to S. mutans in the rhesus monkey. 2) Passive immunization with separated IgG, IgM and IgA from sera of immunized monkeys supports the concept that IgG, unlike IgA or IgM antibodies are protec...

journal_title：Advances in experimental medicine and biology

authors： Lehner T,Russell MW,Wilton JM,Challacombe SJ,Scully CM,Hawkes JE

更新日期：1978-01-01 00:00:00

abstract：:We have isolated a series of five proteins which appear to possess characteristic individual capacities for synthesizing dextrans and binding dextrans. Our suggestion that these proteins comprise an isozyme-like distribution of lectin and enzyme activities is, of course, very speculative and remains to be rigourously ...

journal_title：Advances in experimental medicine and biology

authors： McCabe MM,Hamelik RM

更新日期：1978-01-01 00:00:00

abstract：:1) Motility seems to be required for an intimate association with the intestinal mucosa which is necessary for efficient toxin delivery in the pathogenicity of V. cholerae. 2) A vaccine of semipurified flagella (CF) afforded a high degree of active and passive immunity in the rabbit ileum to both homologous and hetero...

journal_title：Advances in experimental medicine and biology

authors： Yancey RJ,Berry LJ

更新日期：1978-01-01 00:00:00

abstract：:1) An extract of D. carrota induces agglutination of most serotypes of S. mutans but not of S. salivarius or S. mitis. 2) If added to a suspension of mixed bacteria, a piece of D. carrota may selectively sorb S. mutans while S. salivarius and S. mitis only are affected to a minor degree. 3) A saliva coat on the bacter...

journal_title：Advances in experimental medicine and biology

authors： Bratthall D

更新日期：1978-01-01 00:00:00

abstract：:The immune response to insulin, in both mouse and guinea pig , is under control of H-linked immune response genes. When immunized with either pork or beef insulin to CFA, both strain 2 and 13 guinea pigs respond by antigen-specific lymphocyte proliferation and synthesis of specific antibody. The specificity of the eli...

journal_title：Advances in experimental medicine and biology

authors： Rosenthal AS,Rosenwasser LJ,Baskin BL,Schroer J,Thomas JW,Blake JT

更新日期：1978-01-01 00:00:00

abstract：:Synthetic antigens have been of great value in elucidating the relationships between antigen structure and lymphocyte activation. The compound RAT behaves as a monofunctional antigen in guinea pigs and mice, inducing T-lymphocyte responses without appreciable circulating antibody, although the ABA-specific B cell popu...

journal_title：Advances in experimental medicine and biology

authors： Goodman JW,Fong S,Lewis GK,Kamin R,Nitecki DE,Der Balian G

更新日期：1978-01-01 00:00:00

abstract：:Proteolytic enzyme activity, present at both acid and neutral pH values, in cerebrospinal fluid, can be measured by a sensitive assay, which monitors the rate of 125I-basic protein breakdown on polyacrylamide gel electrophoresis. CSF cellular neutral proteinase and supernatant acid proteinase are increased in acute mu...

journal_title：Advances in experimental medicine and biology

authors： Richards PT,Cuzner ML

更新日期：1978-01-01 00:00:00

abstract：:Thromboembolism remains a frequent and serious problem in cardiac patients. Methods to identify the thrombosis prone patient and the identification of safe and effective forms of treatment would be of great value. The accumulating evidence which indicates that abnormalities in platelet tests are often present in cardi...

journal_title：Advances in experimental medicine and biology

authors： Genton E

更新日期：1978-01-01 00:00:00

abstract：:Pertinent data from the literature and in press is summarised and used to construct a model for the molecular arrangement of lipid and protein in the lamellae of compact central nerve myelin. For the lipid phase of myelin the available data is best interpreted in terms of a bilayer arrangement while physical studies s...

journal_title：Advances in experimental medicine and biology

authors： Crang AJ,Rumsby MG

更新日期：1978-01-01 00:00:00

abstract：:With the object of examining the anti-tumour effect of exogenous interferon therapy in man a research programme has been initiated at the Karolinska Hospital. Established cell lines obtained from patients with Burkitt's and other types of lymphoma, leukaemia, osteosarcoma, mammary carcinoma and fibrosarcoma and from f...

journal_title：Advances in experimental medicine and biology

authors： Einhorn S,Strander H

更新日期：1978-01-01 00:00:00

abstract：:Cottage cheese whey protein concentrates, prepared by preconcentration by ultrafiltration followed by gel permeation to remove low molecular weight materials, have the solubility, stability and flavor that make them suitable for fortification of soft drinks and related products. These concentrates are characterized by...

journal_title：Advances in experimental medicine and biology

authors： Holsinger VH

更新日期：1978-01-01 00:00:00

abstract：:Supplementation of diets with free amino acids has not routinely been beneficial and poses a potential risk. Thus, mixing proteins to increase the quality of the dietary protein is attractive. The slope-ratio technique for evaluation of protein quality has serious drawbacks, because the growth response is not linear a...

journal_title：Advances in experimental medicine and biology

authors： Benevenga NJ,Cieslak DG

更新日期：1978-01-01 00:00:00

abstract：:Use of urea as a nonprotein supplement in the feeding of beef cattle and other ruminant animals is a technique of practical application. Urea has also been used in human feeding studies. Its early employment was that of an added source of amino nitrogen in studies designed to determine minimum requirements of the esse...

journal_title：Advances in experimental medicine and biology

authors： Kies C,Fox HM

更新日期：1978-01-01 00:00:00

abstract：:The loss of biological activity upon heating or agitation of human interferons is markedly altered by changing their aqueous environment. Low pH significantly stabilizes liquid fibroblast interferon at 68 degrees C and 37 degrees C whereas chaotropic salts stabilize at 68 degrees C but not at 37 degrees C; this anomal...

journal_title：Advances in experimental medicine and biology

authors： Sedmak JJ,Jameson P,Grossberg SE

更新日期：1978-01-01 00:00:00

abstract：:The most commonly used methods to study the mechanisms of hypocholesterolemic action of therapeutic agents generally determine the turnover of total (exchangeable) cholesterol pools in the body. This approach is based on the view that whatever increases the total load of cholesterol in the body will increase the level...

journal_title：Advances in experimental medicine and biology

authors： Sodhi HS,Kudchodkar BJ,Clifford C,Borhani N,Mason DT

更新日期：1978-01-01 00:00:00

abstract：:Serologic and structural comparisons of the rabbit IgA-g allotypes revealed that 1) the IgA-g allotypes have multiple allotypic determinant sites, 2) the g74, g76 and g77 allotypic specificities have several allotypic determinants in common whereas g75 molecules do not appear to have allotypic determinants in common w...

journal_title：Advances in experimental medicine and biology

authors： Knight KL,Friedenson B,Hanly WC,Malek TR,Peterson BE

更新日期：1978-01-01 00:00:00

abstract：:Proliferation of mononuclear cells was examined with an autoradiography method in the CSF and peripheral blood of 13 patients with multiple sclerosis (MS), serially during activation of disease in one patient with subacute sclerosis panencephalitis (SSPE), and in some control patients with various neurological conditi...

journal_title：Advances in experimental medicine and biology

authors： Reunanen MI,Ilonen J,Järvenpää K

更新日期：1978-01-01 00:00:00

abstract：:1) Although virulence of enteropathogenic E. coli in the pig is essentially associated with the K88 adhesion determinant, protection of the neonate and weanling is not necessarily dependent upon antibodies to this surface antigen. 2) Modification of the surface antigenic characteristics of enteropathogens occurs in th...

journal_title：Advances in experimental medicine and biology

authors： Porter P,Linggood MA,Chidlow J

更新日期：1978-01-01 00:00:00

abstract：:Direct measurements of local oxygen pressure by means of a platinum multiwire electrode were performed to investigate the effect of five different portacaval shunt procedures on hepatic oxygen content in the cirrhotic rat liver. End-to-side shunt, side-to-side shunt, mesenterico caval shunt, splenocaval shunt, and por...

journal_title：Advances in experimental medicine and biology

authors： Broelsch C,Höper J,Kessler M

更新日期：1977-07-04 00:00:00

abstract：:Analysis of the crosslinks epsilon-(gamma-glutamyl) lysine and epsilon- (beta-aspartyl) lysine present in treated wool has been improved by modifying the enzymic digestion. Treatment of wool with either monocarboxylic acid chlorides in dimethylsulfoxide or with 1-fluoro-2,4-dinitrobenzene in the presence of acetate co...

journal_title：Advances in experimental medicine and biology

authors： Ziegler K,Schmitz I,Zahn H

更新日期：1977-01-01 00:00:00

abstract：:Sodium bisulfite is a food and beverage additive. It is also a salt of the urban air pollutant, sulfur dioxide. Bisulfite catalyzes, at neutral pH and physiological temperatures, the transamination reactions of cytosine derivatives with amines. The products of the reactions are N4-substituted cytosines. Both the alpha...

journal_title：Advances in experimental medicine and biology

authors： Shapiro R,Gazit A

更新日期：1977-01-01 00:00:00

abstract：:Macromolecules have been prepared containing native insulin carried by a modified insulin skeleton made by partially thiolating the insulin hexamer and forming intermolecular cross-links through disulphide bridges. Oxidation of partially thiolated insulin (0.5-0.7 SH group/mole), formed by reacting insulin with AHTL, ...

journal_title：Advances in experimental medicine and biology

authors： Mahbouba M,Smith HJ

更新日期：1977-01-01 00:00:00

abstract：:The rates of ethanol oxidation in various species are linked to the rates of general metabolism, and more specifically that of O2 utilization by the liver. After chronic ethanol administration, increased oxidation of ethanol is accompanied by increased total hepatic O2 utilization, as studied in the whole animal, the ...

journal_title：Advances in experimental medicine and biology

authors： Israel Y,Kalant H,Khanna JM,Orrego H,Phillips MJ,Stewart DJ

更新日期：1977-01-01 00:00:00

abstract：:This review covers recent advances in a variety of dyskinesias. Introduction of new drugs for the treatment of myoclonus and sensory biofeedback therapy for focal dystonia are expanding our concepts of these types of movement disorders. Progress in the treatment of action myoclonus is especially noteworthy and has led...

journal_title：Advances in experimental medicine and biology

authors： Fahn S

更新日期：1977-01-01 00:00:00

abstract：:In studies designed to determine the respective functional roles of two bulbospinal monoaminergic pathways to sympathetic preganglionic neurons, both L-dopa and precursors of 5-HT depressed transmission through excitatory spinal reflex and bulbospinal sympathetic pathways. Transmission through spinal reflex pathways w...

journal_title：Advances in experimental medicine and biology

authors： Franz DN,Neumayr RJ,Hare BD

更新日期：1977-01-01 00:00:00

abstract：:Reliable and valid techniques for assessing the alcoholic's disposition to drink would allow researchers to address many issues of clinical significance. This paper reviews some basic issues in behavioral assessment techniques, proposes several criteria for a reasonably general technique for assessing disposition to d...

journal_title：Advances in experimental medicine and biology

authors： Funderburk FR,Allen RP

更新日期：1977-01-01 00:00:00

abstract：:Oligomeric proteins can be intramolecularly cross-linked with polylysine in a reaction in which a water soluble carbodiimide mediates an amide linkage between the protein carboxyl groups and the epsilon-amino groups of polylysine. Studies carried out with a cytochrome p-450 indicate that a small number of molecules in...

journal_title：Advances in experimental medicine and biology

authors： Gordon CN

更新日期：1977-01-01 00:00:00